Conférence Olivieri: Sex chromosomes and speciation

thomas lenormand

Centre d'Ecologie Fonctionnelle et Evolutive - Montpellier

thomas.lenormand@cefe.cnrs.fr

Link to seminar:

https://umontpellier-fr.zoom.us/webinar/register/WN_mSrVnQWDS6OkSPoL-n8qDg

Three major empirical patterns involving sex chromosomes have been observed in higher eukaryotes: Y (or W) chromosomes are often non-recombining and degenerate; when two species hybridize, but one sex is sterile or inviable among hybrid offspring, it is most often the heterogametic sex (XY or ZW)—the so-called Haldane’s rule; and the X (or Z) plays a disproportionately large effect on reproductive isolation compared to autosomes—the so-called large X effect. Each observation has generally received its own tailored explanation involving multiple genetic and evolutionary causes. In this seminar, I will show that these empirical patterns all emerge from a single theory for sex chromosome evolution incorporating the co-evolution of cis and trans-acting regulators of gene expression, and leading to systematic and rapid misexpression of dosage-compensated genes in the heterogametic F1 hybrids, for young or old sex-chromosomes. This theory offers a level of parsimony and generality rarely seen in biology.